AI Article Synopsis
- The prognosis for sarcoma patients is improving due to better understanding of sarcomagenesis and new treatment targets, but aggressive chemotherapy still poses significant side effects that may require ICU care.* -
- A retrospective analysis included 66 sarcoma patients admitted to the ICU from 2005 to 2022, highlighting key factors affecting overall survival such as sex, tumor location, treatment intention, type of chemotherapy, and specific medical scoring systems.* -
- The study confirms the importance of established medical scores in predicting survival for sarcoma patients and calls for more research to enhance ICU treatment strategies.*
Article Abstract
Purpose: Prognosis of sarcoma patients is improving, with a better understanding of sarcomagenesis revealing novel therapeutic targets. However, aggressive chemotherapy remains an essential part of treatment, bearing the risk of severe side effects that require intensive medical treatment. Available data on the characteristics and clinical outcome of sarcoma patients admitted to intensive care units (ICU) are sparse.
Patients And Methods: We performed a retrospective analysis of sarcoma patients admitted to the ICU from 2005 to 2022. Patients ≥18 years with histologically proven sarcoma were included in our study.
Results: Sixty-six patients were eligible for analysis. The following characteristics had significant impact on overall survival: sex (p=0.046), tumour localization (p=0.02), therapeutic intention (p=0.02), line of chemotherapy (p<0.001), SAPS II score (p=0.03) and SOFA score (p=0.02).
Conclusion: Our study confirms the predictive relevance of established sepsis and performance scores in sarcoma patients. For overall survival, common clinical characteristics are also of significant value. Further investigation is needed to optimize ICU treatment of sarcoma patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065007 | PMC |
| http://dx.doi.org/10.2147/CMAR.S400430 | DOI Listing |
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