Objective: To determine whether changes in pulmonary vascular resistance (PVR) and changes in pulmonary artery compliance ( ) are associated with changes in exercise capacity assessed either by changes in peak oxygen consumption (' ) or by changes in 6-min walk distance (6MWD) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing balloon pulmonary angioplasty (BPA).

Methods: Invasive haemodynamic parameters, peak ' and 6MWD were measured within 24 h, before and after BPA (interval 3.1±2.4 months) in 34 CTEPH patients without significant cardiac and/or pulmonary comorbidities, of whom 24 received at least one pulmonary hypertension-specific treatment. was calculated according to the pulse pressure method: =((SV/PP)/1.76+0.1), where SV is the stroke volume and PP is the pulse pressure. The resistance-compliance (RC)-time of the pulmonary circulation was calculated as the PVR and product.

Results: After BPA, PVR decreased (562±234 290±106 dyn·s·cm; p<0.001); increased (0.90±0.36 1.63±0.65 mL·mmHg; p<0.001); but RC-time did not change (0.325±0.069 0.321±0.083 s; p=0.75). There were improvements in peak ' (1.11±0.35 1.30±0.33 L·min; p<0.001) and in 6MWD (393±119 432±100 m; p<0.001). After adjustment for age, height, weight and gender, changes in exercise capacity, assessed either by peak ' or 6MWD, were significantly associated with changes in PVR, but not with changes in .

Conclusions: Contrary to what has been reported in CTEPH patients undergoing pulmonary endarterectomy, in CTEPH patients undergoing BPA, changes in exercise capacity were not associated with changes in .

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052638PMC
http://dx.doi.org/10.1183/23120541.00590-2022DOI Listing

Publication Analysis

Top Keywords

pulmonary
10
exercise capacity
8
balloon pulmonary
8
pulmonary angioplasty
8
chronic thromboembolic
8
thromboembolic pulmonary
8
pulmonary hypertension
8
changes pulmonary
8
pulse pressure
8
changes
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!