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Objectives: The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER)results in a state known as "ER stress". It can affect the fate of proteins and play a crucial role in the pathogenesis of several diseases. In this study, we investigated the protective effect of chlorogenic acid (CA) on the inflammation and apoptosis of tunicamycin-induced ER stress in mice.
Materials And Methods: We categorized mice into six groups: Saline, Vehicle, CA, TM, CA 20-TM, and CA 50-TM. The mice received CA (20 or 50 mg/kg) before intraperitoneal tunicamycin injection. After 72 hr of treatment, serum biochemical analysis, histopathological alterations, protein and/or mRNA levels of steatosis, and inflammatory and apoptotic markers were investigated by ELISA and/or RT-PCR.
Results: We found that 20 mg/kg CA decreased mRNA levels of , and . Moreover, CA supplementation prevented TM-induced liver injury through changes in lipid accumulation and lipogenesis markers of steatosis ( ), and exerted an inhibitory effect on inflammatory ( and ) and apoptotic markers (caspase 3, , , and ), of liver tissue in ER stress mice.
Conclusion: These data suggest that CA ameliorates hepatic apoptosis and inflammation by reducing NF-κB and Caspase 3 as related key factors between inflammation and apoptosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008392 | PMC |
| http://dx.doi.org/10.22038/IJBMS.2023.66827.14659 | DOI Listing |
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