Objectives: In this study, we aimed to evaluate and compare the nephroprotective and possible anti-diabetic effects of vitamin E, metformin, and .
Materials And Methods: Thirty male Wistar Albino rats were randomly divided into control, experimental diabetes (DM), vitamin E + DM, Metformin + DM, and + DM. For experimental diabetes induction, IP 45 mg/kg streptozotocin was administered. Rats in vitamin E + DM, Metformin + DM, and + DM received 100 mg/kg vitamin E, 100 mg/kg metformin, and 2.5 ml/kg oil for 56 days. After the experiment, all animals were sacrificed, and blood and kidney samples were collected.
Results: The blood urea level of the DM group was significantly higher (<0.01) than the control group. Urea levels in vitamin E, metformin, and groups were similar to the control group (>0.05) but significantly different from the DM group (<0.01). Bax, caspase-3, and caspase-9 immunopositivity intensity were quite low in the control group, and similar to the group (>0.05). Bcl-2 immunopositivity density was highest in the group, similar to the control group in terms of percentile area (>0.05).
Conclusion: When all three treatment methods were compared in terms of their effectiveness in alleviating DM and DN, it was determined that the most successful result was obtained with oil.
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| http://dx.doi.org/10.22038/IJBMS.2023.68051.14876 | DOI Listing |
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