A 3-year-old, neutered Rottweiler dog was brought to a veterinary clinic with recurrent epistaxis and lethargy. A profound thrombocytopenia was identified, suggesting immune-mediated thrombocytopenia (IMTP). Immunosuppressive therapy (prednisone and mycophenolate mofetil) was initiated. Within 3 wk of commencing treatment, platelet counts and clinical signs improved.
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