The nuclear receptors and are highly conserved and function to regulate molting and reproduction in both hemimetabolous and holometabolous insects. However, their roles in are largely unknown. In the present study, we discover that and are activated in the nymph stages by ecdysone signaling. Transcription disruption of and expression prevents nymph ecdysis and metamorphosis, which leads to abnormal appearance, malformed ovaries, and lethal phenotypes. In addition, we demonstrate that and regulate molting and reproduction by interacting with the intrinsic 20E and JH signaling pathways. Our work offers a deep insight into the action mechanisms of and in insects. Moreover, and could properly be exploited as potential target genes for developing RNAi-based pesticides to control .
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| http://dx.doi.org/10.3389/fphys.2023.1123583 | DOI Listing |
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