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| http://dx.doi.org/10.3389/fphar.2023.1165596 | DOI Listing |
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Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health.
Curr Pharmacol Rep
December 2024
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854 USA.
Purpose Of Review: Dietary phytochemicals, bioactive compounds derived from plants, have gained increasing attention for their potential role in cancer prevention. Among these, NRF2 (nuclear factor erythroid 2-related factor 2) activating dietary phytochemicals such as curcumin, sulforaphane, ursolic acid, and cyanidin have demonstrated significant antioxidant and anti-inflammatory properties, making them promising agents in chemoprevention. This review examines the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of these dietary phytochemicals, with a focus on their NRF2-mediated effects in cancer prevention.
View Article and Find Full Text PDFEditorial: Phytochemical-based nanoformulations to tackle drug resistance in cancer.
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Faculty of Pharmacy, Department of Pharmacology, Drug Application and Research Center, Erciyes University, Kayseri, Türkiye.
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