AI Article Synopsis
- - A 56-year-old woman was treated for acute myeloid leukemia (AML) and had a condition called monoclonal gammopathy of undetermined significance (MGUS), eventually undergoing an allogeneic stem cell transplant after achieving second complete remission.
- - Four years post-transplant, her MGUS progressed to multiple myeloma, leading to intensive treatment with an autologous stem cell transplant after successfully mobilizing stem cells.
- - The report highlights two key points: the graft versus leukemia effect successfully cured her AML but was ineffective against the myeloma, and it was possible to mobilize stem cells for autologous transplantation after an allogeneic transplant.
Article Abstract
We describe here a 56-years -old woman cured in our institution for an acute myeloid leukemia (AML) and a monoclonal gammopathy of undetermined significance (MGUS). In order to treat AML, underwent allogeneic stem cell transplantation in second complete remission. Four years after transplant, MGUS evolved to multiple myeloma and was intensively treated with "autologous" transplant after successful mobilization. This report illustrates: (i) a lack of efficacy of graft versus myeloma effect in a patient probably cured of AML by graft versus leukaemia effect; (ii) the ability to mobilize peripheral blood stem cells in order to perform "autologous" transplantation after allogeneic transplantation.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050635 | PMC |
| http://dx.doi.org/10.1016/j.lrr.2023.100366 | DOI Listing |
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