AI Article Synopsis
- The study investigates the changes in soluble suppression of tumorigenicity 2 (sST2) levels and echocardiography parameters before and one month after permanent pacemaker (PPM) implantation in symptomatic bradycardia patients.
- It involved 49 patients who had preserved ejection fraction and found statistically significant differences in sST2 levels before and after the procedure (23.4±28.4 ng/ml vs 39.9±63.7 ng/ml, p=0.001).
- The results indicate that significant early cardiac remodeling occurs within one month of PPM implantation, as shown by the increase in sST2 levels.
Article Abstract
Aim: This study aims to evaluate: the difference of soluble suppression of tumorigenicity 2 (sST2) level, a biomarker for cardiac remodeling and echocardiography parameters value prior to and 1 month after implantation; and the association between pacemaker parameters and pacemaker mode along with delta sST2 levels.
Materials & Methods: This prospective cohort study enrolled all symptomatic bradycardia patients aged >18 years with preserved ejection fraction who underwent permanent pacemaker (PPM) implantation.
Results: A total of 49 patients were included in this study. The sST2 level (ng/ml) were significantly different between prior and 1 month following PPM implantation (23.4 ± 28.4 vs 39.9 ± 63.7; p = 0.001).
Conclusion: The early cardiac remodeling has occurred within 1 month after PPM implantation as indicated by increasing delta sST2 level.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051037 | PMC |
| http://dx.doi.org/10.2144/fsoa-2023-0001 | DOI Listing |
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