AI Article Synopsis
- Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects over 5% of children and adolescents globally, with rising prevalence rates over recent decades.
- *The causes of ADHD are believed to involve a combination of genetic (polygenic) and environmental factors, although the specific molecular mechanisms aren't completely understood.
- *This study focuses on creating cell lines from ADHD patients and healthy controls using Sendai virus, which will assist in exploring ADHD at molecular and cellular levels to identify potential treatment strategies and predictive markers.
Article Abstract
Attention-deficit hyperactivity disorder is a neurodevelopmental disorder which prevalence has been increasing in the past decades, affecting more than 5% of children, adolescents worldwide. Regarding etiology, polygenic, environmental factors contribute to the occurrence of ADHD even though molecular mechanisms are not known. Understanding the pathophysiology in patient-specific cells is crucial for the discovery of potential predictive markers, the establishment of new therapeutic targets. In this study, we generated further lines from ADHD patients, healthy controls using Sendai virus transduction, which may help on the study of ADHD at the molecular, cellular levels.
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| http://dx.doi.org/10.1016/j.scr.2023.103084 | DOI Listing |
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