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Targeting inerleukin-6 for renoprotection.
Front Immunol
December 2024
Department of Pharmacology, Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Sterile inflammation has been increasingly recognized as a hallmark of non-infectious kidney diseases. Induction of pro-inflammatory cytokines in injured kidney tissue promotes infiltration of immune cells serving to clear cell debris and facilitate tissue repair. However, excessive or prolonged inflammatory response has been associated with immune-mediated tissue damage, nephron loss, and development of renal fibrosis.
View Article and Find Full Text PDF"I'm trying to take the lead from my child": experiences Parenting Young Nonbinary Children.
Child Adolesc Psychiatry Ment Health
September 2024
Eliot-Pearson Department of Child Study and Human Development (EPCSHD), Tufts University, Medford, USA.
Background: While research has emphasized the importance of parental support for LGBTQIA + youth wellbeing, there remains limited understanding of parental experiences with nonbinary children, particularly those prepubescent. This study aimed to explore how parents of nonbinary children ages 5-8 learn to support their child's identity, examining initial reactions, emotional processes, supportive behaviors, societal responses, and associated challenges and rewards.
Methods: A qualitative study was conducted using Reflexive Thematic Analysis (RTA) within a framework of ontological relativism and epistemological constructivism.
Polarized metal-metal multiple bonding and reactivity of phosphinoamide-bridged heterobimetallic group IV/cobalt compounds.
Dalton Trans
October 2024
Department of Chemistry and Biochemistry, The Ohio State University, 100 W, 18th Ave, Columbus, OH 43210, USA.
Heterobimetallic complexes are studied for their ability to mimic biological systems as well as active sites in heterogeneous catalysts. While specific interest in early/late heterobimetallic systems has fluctuated, they serve as important models to fundamentally understand metal-metal bonding. Specifically, the polarized metal-metal multiple bonds formed in highly reduced early/late heterobimetallic complexes exemplify how each metal modulates the electronic environment and reactivity of the complex as a whole.
View Article and Find Full Text PDF"I feel like I'm living the authenticity of my being": gender identity developmental trajectories of trans youth in Portugal.
Int J Transgend Health
January 2024
Center for Psychology at University of Porto, Faculty of Psychology and Education Sciences (FPCEUP), University of Porto, Portugal.
Article Synopsis
- - The study investigates the gender identity (GI) development of young Portuguese trans people, emphasizing the milestones involved in their identity construction during late adolescence and early adulthood.
- - Six main themes emerged from interviews with 16 participants aged 16 to 26, highlighting discomfort with gender assigned at birth, body discomfort, discovery and disclosure of trans identities, support perceived from others, and the importance of living authentically.
- - Utilizing life course theory, the research identifies critical transition moments and social influences affecting trans youth in Portugal, contributing valuable insights for better socio-legal policies concerning trans individuals internationally.
UV-Vis spectrophotometric determination of rare earth elements (REE) speciation at near-neutral to alkaline pH. Part I: -cresol purple properties from 25-75 °C and Er hydrolysis.
Dalton Trans
August 2024
New Mexico Bureau of Geology and Mineral Resources, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, NM 87801, USA.
The speciation and mobility of rare earth elements (REE) strongly depends on pH, which controls the formation of charged aqueous hydroxyl species. The latter potentially play an important role in controlling heavy REE adsorption on clay minerals in near-neutral to alkaline waters such as in regolith-hosted REE mineral deposits. However, accurate REE hydrolysis constants are needed for developing geochemical models that can predict the role of these charged species in natural systems.
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