AI Article Synopsis
- Immune and inflammatory responses play a crucial role in pulmonary hypertension (PH), yet the immune system's response in patients with high-altitude pulmonary hypertension (HAPH) is not well understood.
- * Using single-cell transcriptomics, the study identifies significant changes in monocyte populations in the blood of HAPH patients, particularly increases in non-classical (C1) and intermediate (C2) monocytes.
- * The findings suggest that decreased levels of hypoxia-inducible transcription factor-1α (HIF-1α) in all monocyte types may be linked to the development of HAPH, highlighting a potential immune-related mechanism in this condition.*
Article Abstract
Immune and inflammatory responses have an important function in the pathophysiology of pulmonary hypertension (PH). However, little is known about the immune landscape in peripheral circulation in patients with high-altitude pulmonary hypertension (HAPH). We apply single-cell transcriptomics to characterize the monocytes that are significantly enriched in the peripheral blood mononuclear cells (PBMC) of HAPH patients. We discover an increase in C1 (non-classical) and C2 (intermediate) monocytes in PBMCs and a decrease in hypoxia-inducible transcription factor-1α (HIF-1α) in all monocyte subsets associated with HAPH. In addition, we demonstrate that similar immune adaptations may exist in HAPH and PH. Overall, we characterize an immune cell atlas of the peripheral blood in HAPH patients. Our data provide evidence that specific monocyte subsets and HIF-1α downregulation might be implicated in the pathogenesis of HAPH.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066231 | PMC |
| http://dx.doi.org/10.1038/s41467-023-37527-4 | DOI Listing |
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