AI Article Synopsis

  • - Bone lead is identified as a more reliable biomarker for chronic lead exposure in communities, and a new portable X-ray fluorescence (XRF) device allows for quick measurements.
  • - The study tested bone lead levels across five different bone sites and found no significant differences in measurements from these locations.
  • - The average bone lead concentration was 21.6 μg/g, and while the portable XRF can measure cumulative lead exposure accurately, the tibia is recommended for consistent comparison across studies.

Article Abstract

Bone lead serves as a better, more accessible biomarker to many communities experiencing chronic exposure to lead. A new method using low energy x-ray fluorescence in a handheld device (portable XRF) allows us to measure this chronic biomarker in only a few minutes. However, many unknowns remain about this biomarker measured using a new low energy x-ray technique. The low energy of the new method was theorized to measure a slightly different portion of the bone than previous techniques, which could influence measurements at different bone sites and types. We tested how bone measurements varied across five bone sites: mid-tibial shaft, proximal tibia, distal tibia (ankle), ilium, and cranium. We found bone lead measurements are not significantly different between skeletal elements when measured using a portable XRF. On average, bone lead in the repository samples was measured to be 21.6 ± 21.3 μg/g with an XRF detection limit of 2.1 ± 0.5 μg/g. Cumulative lead exposure can be effectively measured using the portable XRF on a variety of bone types, but the tibia should be preferentially measured to compare between studies and individuals.

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Source
http://dx.doi.org/10.1016/j.scitotenv.2023.163197DOI Listing

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