A simple, efficient method has been developed for the Co-H-catalyzed aerobic C-C bond cleavage of tertiary allylic alcohols to access ketones. This novel approach presents excellent chemoselectivity, good functional group compatibility, and high yields. This reaction occurs through a HAT-initiated peroxide intermediate, and an adjacent glycol-type diradical fragmentation process is recommended.
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| http://dx.doi.org/10.1021/acs.orglett.3c00556 | DOI Listing |
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