AI Article Synopsis
- A new efficient method has been developed for synthesizing tertiary alcohols using a combination of an enzyme system (laccase/TEMPO/O) and polar organometallic reagents (RLi/RMgX).
- This hybrid one-pot tandem approach allows for fast and selective reactions under mild, non-traditional conditions, such as room temperature and without a protective atmosphere.
- The process eliminates the need for complex intermediate purification steps, making it a more streamlined and convenient alternative in organic synthesis.
Article Abstract
The highly efficient biodeoximation of aromatic ketoximes, promoted by the enzymatic oxidative system laccase/TEMPO/O, has been successfully assembled with the fast and chemoselective addition of highly-polar s-block organometallic reagents (RLi/RMgX) to highly-substituted tertiary alcohols. By using this hybrid one-pot tandem protocol, tertiary alcohols have been selectively synthesized in good yields and under mild and bench-type reaction conditions (room temperature, the absence of a protecting atmosphere and aqueous media, which are non-typical conditions for polar organometallic reagents). The overall hybrid one-pot tandem transformation amalgamates two distant organic synthetic tools (RLi/RMgX reagents and enzymes) without the need for any tedious and energy/time-consuming intermediate isolation/purification steps.
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| http://dx.doi.org/10.1039/d3ob00285c | DOI Listing |
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