AI Article Synopsis
- The study aimed to compare the effectiveness of the Nerbridge, an artificial nerve conduit, with direct nerve suture in repairing a sciatic nerve injury in rats.
- Sixty-six female Lewis rats were divided into four groups: one receiving no reconstruction, one with direct suture, and two using the Nerbridge for short-gap interposition.
- Results showed that both the SGI (Nerbridge) and direct suture groups had similar recovery and less muscle atrophy compared to the no-reconstruction group, suggesting Nerbridge is a viable alternative for nerve repair.
Article Abstract
Unlabelled: The aim of this study was to evaluate whether the Nerbridge, an artificial polyglycolic acid conduit with collagen matrix, is comparable to direct nerve suture in a rat sciatic nerve injury model in a short-gap interposition (SGI) setting.
Methods: Sixty-six female Lewis rats were randomly divided into the sham group (n = 13); no reconstruction (no-recon) group (n = 13; rat model with 10 mm sciatic nerve defect); direct group (n = 20; rat sciatic nerve injury directly connected by 10-0 Nylon); and SGI group (n = 20; sciatic nerve injury repaired using 5-mm Nerbridge). Motor function and histological recovery were evaluated. The sciatic nerve and gastrocnemius muscle were harvested for quantification of the degree of nerve regeneration and muscle atrophy.
Results: The SGI and direct groups achieved equal recovery in both functional and histological outcomes. At weeks 3 and 8 postsurgery, there was a significant improvement in the sciatic functional index of the SGI group when compared with that of the no-recon group ( < 0.05). Furthermore, the direct and SGI groups had less muscle atrophy at 4 and 8 weeks postsurgery compared with the no-recon group ( < 0.05). The axon density and diameter at the distal site in the SGI group were significantly higher than that in the no-recon group and comparable to that in the direct and sham groups.
Conclusion: An artificial nerve conduit has equal potential as direct suture in motor nerve reconstruction when used in the SGI setting.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043553 | PMC |
| http://dx.doi.org/10.1097/GOX.0000000000004875 | DOI Listing |
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