AI Article Synopsis
- Multifunctional nanoparticles are promising for tumor diagnosis and therapy, but creating effective ones is challenging.
- A new organic agent, Aza/I-BDP, was developed by combining specific chemical compounds, resulting in nanoparticles that are biocompatible and exhibit efficient light conversion and stability.
- The coassembly of Aza/I-BDP with a copolymer enhances its brightness and prevents aggregation, allowing these nanoparticles to be used for advanced imaging and targeted treatment of tumors.
Article Abstract
Multifunctional nanoparticles integrating accurate multi-diagnosis and efficient therapy hold great prospects in tumor theranostics. However, it is still a challenging task to develop multifunctional nanoparticles for imaging-guided effective eradication of tumors. Herein, we developed a near-infrared (NIR) organic agent Aza/I-BDP by coupling 2,6-diiodo-dipyrromethene (2,6-diiodo-BODIPY) with aza-boron-dipyrromethene (Aza-BODIPY). Through encapsulating with an amphiphilic biocompatible copolymer DSPE-mPEG, well-distributed Aza/I-BDP nanoparticles (NPs) were developed, which exhibited high O generation, high photothermal conversion efficiency, and excellent photo-stability. Notably, coassembly of Aza/I-BDP and DSPE-mPEG effectively inhibits H-aggregation of Aza/I-BDP in aqueous solution and enhances the brightness simultaneously up to 31-fold. More importantly, experiments demonstrated that Aza/I-BDP NPs might be used for NIR fluorescent and photoacoustic imaging-guided photodynamic and photothermal therapy.
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| http://dx.doi.org/10.1021/acsabm.3c00083 | DOI Listing |
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