AI Article Synopsis
- IgA nephropathy (IgAN) and minimal change disease (MCD) are the most frequently reported glomerular diseases following COVID-19 vaccinations, especially mRNA vaccines, along with others like membranous nephropathy.
- A global registry was created to collect anonymized data on patients with glomerular diseases suspected after vaccination, focusing on vaccination details, kidney function, and treatment outcomes.
- Results show that while IgAN and MCD have a better chance of kidney function recovery and reduced proteinuria within 4–6 months post-vaccination, causality remains unproven despite a temporal link.
Article Abstract
Key Points: IgAN and MCD are the most common glomerular diseases reported after COVID-19 vaccination, particularly after mRNA vaccination. Membranous nephropathy, pauci-immune GN, and collapsing GN have also been attributed to COVID-19 vaccination, some with dual histologies. Recovery of kidney function and proteinuria remission is more likely in IgAN and MCD by 4–6 months compared with the other glomerular diseases.
Background: Patients with glomerular disease (GD) with various renal histologies have been reported after vaccination against SARS-CoV-2. Causality has not been established, and the long-term outcomes are not known. To better characterize the GDs and clinical courses/outcomes, we created the International Registry of COVID-19 vaccination and Glomerulonephritis to study in aggregate patients with GN suspected after COVID-19 vaccine exposure.
Methods: A REDCap survey was used for anonymized data collection. Detailed information on vaccination type and timing and GD histology were recorded in the registry. We collected serial information on laboratory values (before and after vaccination and during follow-up), treatments, and kidney-related outcomes.
Results: Ninety-eight patients with GD were entered into the registry over 11 months from 44 centers throughout the world. Median follow-up was 89 days after diagnosis. IgA nephropathy (IgAN) and minimal change disease (MCD) were the most common kidney diseases reported. Recovery of kidney function and remission of proteinuria were more likely in IgAN and MCD at 4–6 months than with pauci-immune GN/vasculitis and membranous nephropathy.
Conclusions: The development of GD after vaccination against SARS-CoV-2 may be a very rare adverse event. Temporal association is present for IgAN and MCD, but causality is not firmly established. Kidney outcomes for IgAN and MCD are favorable. No changes in vaccination risk-benefit assessment are recommended based on these findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103269 | PMC |
| http://dx.doi.org/10.34067/KID.0006832022 | DOI Listing |
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