Every research project has limitations. The limitations that authors acknowledge in their articles offer a glimpse into some of the concerns that occupy a field's attention. We examine the types of limitations authors discuss in their published articles by categorizing them according to the four validities framework and investigate whether the field's attention to each of the four validities has shifted from 2010 to 2020. We selected one journal in social and personality psychology (), the subfield most in the crosshairs of psychology's replication crisis. We sampled 440 articles (with half of those articles containing a subsection explicitly addressing limitations), and we identified and categorized 831 limitations across the 440 articles. Articles with limitations sections reported more limitations than those without (avg. 2.6 vs. 1.2 limitations per article). Threats to external validity were the most common type of reported limitation (est. 52% of articles), and threats to statistical conclusion validity were the least common (est. 17% of articles). Authors reported slightly more limitations over time. Despite the extensive attention paid to statistical conclusion validity in the scientific discourse throughout psychology's credibility revolution, our results suggest that concerns about statistics-related issues were not reflected in social and personality psychologists' reported limitations. The high prevalence of limitations concerning external validity might suggest it is time that we improve our practices in this area, rather than apologizing for these limitations after the fact. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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http://dx.doi.org/10.1037/pspp0000458 | DOI Listing |
G3 (Bethesda)
January 2025
School of Life Sciences, Center for Evolution & Medicine, Arizona State University, Tempe, AZ 85281, USA.
The demographic history of a population, and the distribution of fitness effects (DFE) of newly arising mutations in functional genomic regions, are fundamental factors dictating both genetic variation and evolutionary trajectories. Although both demographic and DFE inference has been performed extensively in humans, these approaches have generally either been limited to simple demographic models involving a single population, or, where a complex population history has been inferred, without accounting for the potentially confounding effects of selection at linked sites. Taking advantage of the coding-sparse nature of the genome, we propose a 2-step approach in which coalescent simulations are first used to infer a complex multi-population demographic model, utilizing large non-functional regions that are likely free from the effects of background selection.
View Article and Find Full Text PDFBr J Dermatol
January 2025
Centre of Evidence Based Dermatology, School of Medicine, Faculty of Medicine & Health Sciences, University of Nottingham, UK.
Background: Randomised controlled trials (RCTs) evaluating new systemic treatments for atopic dermatitis (AD) have increased dramatically over the last decade. These trials often incorporate topical therapies either as permitted concomitant or rescue treatments. Differential use of these topicals post-randomisation introduces potential bias as they may nullify or exaggerate treatment responses.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Department of Dermatology, Daping Hospital, Army Medical University, No. 10, Changjiang Branch Road, Yuzhong District, Chongqing 400042, China.
Psoriasis affects a significant proportion of the worldwide population and causes an extremely heavy psychological and physical burden. The existing therapeutic schemes have many deficiencies such as limited efficacies and various side effects. Therefore, novel ways of treating psoriasis are urgently needed.
View Article and Find Full Text PDFJ Am Assoc Nurse Pract
January 2025
Division of Cardiology, Department of Medicine, Duke Health Integrated Practice, Duke University Health System, Durham, North Carolina.
Background: Increasing patient demand and clinician burnout in rheumatology practices have highlighted the need for more efficient models of care (MOC). Interprofessional collaboration is essential for improving patient outcomes and clinician satisfaction.
Local Problem: Our current MOC lacks standardization and formal integration of Nurse Practitioners (NPs) and Physician Assistants (PAs), resulting in reduced clinician satisfaction and limited patient access.
ACS Appl Bio Mater
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Cuproptosis exhibits enormous application prospects in treatment. However, cuproptosis-based therapy is impeded by the limited intracellular copper ions, the nonspecific delivery, uncontrollable release, and chelation of endogenous overproduced glutathione (GSH). In this work, an ultrasound-triggered nanosonosensitizer (p-TiO-Cu(I)) was constructed for Cu(I) delivery, on-demand release, GSH consumption, and deeper tissue response.
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