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Temporal properties of transcutaneous direct current motor conduction block.

J Neural Eng

January 2025

Physical Medicine and Rehabilitation, The MetroHealth System, 2500 Metrohealth Dr, Cleveland, OH 44109, USA, Cleveland, Ohio, 44109-1998, UNITED STATES.

Direct current (DC) electrical block of peripheral nerve conduction shows promise for clinical applications to treat spasticity, pain, and cardiac arrhythmias. Most previous work has used invasive nerve cuffs. Here we investigate the potential of non-invasive transcutaneous direct current motor block (tDCB).

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Neuropathic pain (NP) imposes a significant burden on individuals, manifesting as nociceptive anaphylaxis, hypersensitivity, and spontaneous pain. Previous studies have shown that traumatic stress in the nervous system can lead to excessive production of hydrogen sulfide (HS) in the gut. As a toxic gas, it can damage the nervous system through the gut-brain axis.

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Background: Management of respiratory motion during radiation therapy is essential for accurate dose delivery and minimizing the risk to organs. In diagnostic imaging, respiratory monitoring is required for confirmation of breath-hold and four-dimensional computed tomography (CT) reconstruction. Although respiratory monitoring systems are widely used in radiation therapy, they are not often used for diagnostic imaging, where they could improve image quality.

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We consider a dynamical system undergoing a saddle-node bifurcation with an explicitly time-dependent parameter p(t). The combined dynamics can be considered a dynamical system where p is a slowly evolving parameter. Here, we investigate settings where the parameter features an overshoot.

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