Whether COVID-19-related morbidity and mortality are increased in splenectomized patients is unknown. The study by Bianchi et al. suggests increased hospitalizations and mortality rates in splenectomized patients, despite observing similar infection rates when compared to the general population. Commentary on: Bianchi et al. Burden of COVID19 disease and vaccine coverages in Apulian splenectomized patients. A retrospective observational study. Br J Haematol 2023;201:1072-1080.
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http://dx.doi.org/10.1111/bjh.18767 | DOI Listing |
Eur J Cancer
December 2024
Department of Dermatology and Allergy, LMU University Hospital, LMU Munich, Munich, Germany; Department of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany. Electronic address:
Br J Haematol
October 2024
Department of Internal Medicine and Infectious Diseases, University Hospital Centre of Bordeaux, Pessac, France.
In primary immune thrombocytopenia (ITP), predictors of disease evolution and treatment response are needed. Data based on the site of platelet destruction are scarce. We performed a retrospective single-centre study of adult patients with primary ITP undergoing at least one Indium-111 platelet scintigraphy (IPS) between 2009 and 2018.
View Article and Find Full Text PDFLeuk Lymphoma
September 2024
Clinic of Hematology, AOU Ospedali Riuniti, Ancona, Italy.
Patient diagnosed with lymphoma presents a greater risk of infection, mainly if undergoing anti-CD20 therapy, splenectomized, hypogammaglobulinemic. They can therefore benefit from a vaccination program, especially in the watchful waiting phases or before starting oncologic treatment. The COVID-19 pandemic has raised awareness on vaccinations in frail patients, but a homogeneous approach has yet to be achieved across different vaccinations.
View Article and Find Full Text PDFMicroorganisms
July 2024
Department of Infectious Diseases, University Medical Centre Ljubljana, 1525 Ljubljana, Slovenia.
Information on asplenic Lyme borreliosis (LB) patients with erythema migrans (EM) is lacking. We compared the course and outcome of 26 EM episodes in 24 post-trauma splenectomized patients (median age 51 years) diagnosed at a single clinical center in Slovenia during 1994-2023 with those of 52 age- and sex-matched patients with EM but with no history of splenectomy. All patients were followed for one year.
View Article and Find Full Text PDFBlood Coagul Fibrinolysis
September 2024
Atrium Health Levine Cancer, Department of Hematologic Oncology and Blood Disorders, Concord, North Carolina, USA.
Fostamatinib is a spleen tyrosine kinase inhibitor indicated for the treatment of chronic immune thrombocytopenia (ITP) unresponsive to a previous treatment. Real-world studies evaluating the utilization and effectiveness of fostamatinib outside the context of a clinical trial are lacking. The objective of this analysis was to evaluate the effectiveness of fostamatinib for the treatment of ITP in a real-world cohort.
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