Computational analysis of a microRNA signature for poor prognosis suggests a microRNA-controlled stemness pathway in paediatric acute leukaemia.

Esperanza-Cebollada E., et al. found a group of 24 microRNAs, to be differentially expressed between two groups of paediatric acute myeloid leukaemia (AML) cases with distinct outcomes. The main target of this microRNA signature is SOCS2, a gene that controls stemness. The results of this study may open doors for further investigation of the role for microRNAs in poor prognostic paediatric AML. Commentary on: Esperanza-Cebollada et al. A miRNA signature related to stemness identifies high-risk patients in paediatric acute myeloid leukaemia. Br J Haematol 2023;202:96-110.