Background: It has been reported that there is a close correlation between triglycerides to high density lipoprotein cholesterol ratio (TG/HDL-C) and hypertension, but there are differences between different researches. The purpose of this study is to investigate the relationship between TG/HDL-C and hypertension in Chinese adults.
Methods: In this study, the open data for secondary analysis were obtained from DATADRYAD website (www.datadryad.org), and the raw data were from the Rich Healthcare Group Health. A total of 112 798 patients were enrolled in this study. The TG/HDL-C ratio was calculated as TG divided by HDL-C. Hypertension was defined as SBP ≥ 140 mmHg or DBP ≥ 90 mmHg. Logistic regression model was used to analyze the relationship between TG/HDL-C and hypertension. Sensitivity analysis and subgroup analysis were carried out to ensure the stability of the results.
Results: After adjusting for confounding factors, the increase of TG/HDL-C was independently associated with the risk of hypertension (HR, 95% CI; 1.11,1.07 ~ 1.16). Compared with the lowest quartile (Q1), the risk of hypertension increased with the increase of TG/HDL-C (Q2, Q3 and Q4) [HR, 95% CI; 1.17 (1.06-1.29); 1.25 (1.13-1.38); 1.37 (1.24-1.52)]. Moreover, the relationship between TG/HDL-C and hypertension was not linear, but showed the saturation effect, and the slope of the curve decreases with the increase of TG/HDL-C. Results of subgroup analysis showed that there was a significant correlation among BMI (>=18.5 kg/m2, <24 kg/m2) and females.
Conclusion: TG/HDL-C is positively associated with increased risk of hypertension in Chinese adults, especially women and normal BMI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10641963.2023.2195996 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers and Seaweed-Based Nutritional Interventions in Metabolic Syndrome: A Comprehensive Review.
Mar Drugs
December 2024
Centre for Functional Ecology: Science for People & Planet, Marine Resources, Conservation and Technology-Marine Algae Lab, Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal.
Metabolic Syndrome (MetS) is a complex, multifactorial condition characterized by risk factors such as abdominal obesity, insulin resistance, dyslipidemia and hypertension, which significantly contribute to the development of cardiovascular disease (CVD), the leading cause of death worldwide. Early identification and effective monitoring of MetS is crucial for preventing serious cardiovascular complications. This article provides a comprehensive overview of various biomarkers associated with MetS, including lipid profile markers (triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio), inflammatory markers (interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), plasminogen activator inhibitor type 1 (PAI-1), C-reactive protein (CRP), leptin/adiponectin ratio, omentin and fetuin-A/adiponectin ratio), oxidative stress markers (lipid peroxides, protein and nucleic acid oxidation, gamma-glutamyl transferase (GGT), uric acid) and microRNAs (miRNAs) such as miR-15a-5p, miR5-17-5p and miR-24-3p.
View Article and Find Full Text PDFClinical Characteristics, Risk Factors, and Predictors of Nonobese Fatty Liver Disease: A Cross-Sectional Study.
Diabetes Metab Syndr Obes
November 2024
Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People's Republic of China.
Purpose: This study aimed to investigate the risk factors and predictors of non-obese fatty liver disease in the Chinese population.
Patients And Methods: A total of 6,014 adults who underwent physical examinations at Union Hospital of Huazhong University of Science and Technology from March 2019 to March 2023 were included in this study. Fatty liver disease was diagnosed based on at least two of the following criteria: diffuse echo patterns relative to the liver, spleen, and kidney; ultrasonic beam attenuation; and poor intrahepatic visual details.
Body adiposity index and other indexes of body composition in predicting cardiovascular disease in the Chinese population: A Cohort study.
Perfusion
November 2024
Department of Public Health, Soochow university, Suzhou, Jiangsu, China.
Objective: The purpose of this study was to compare the ability of four obesity indicators, including waist circumference (WC), body mass index (BMI), body adiposity index (BAI), and waist-to-height ratio (WHtR) on prediction for incident cardiovascular disease (CVD) in Chinese Han population.
Methods: We analyzed data from a prospective population cohort of 3598 participants aged 35 to 74 years from Jiangsu China. The logistic regression model was used to analyze the association between four obesity indicators and CVD risk.
Association of Triglyceride-Glucose Index, Triglyceride to High-Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension.
J Clin Hypertens (Greenwich)
October 2024
EICU, Anzhen Hospital of the Capital University of Medical Sciences, Beijing, China.
The objective of this study was to investigate the association between triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c), triglyceride-glucose index (TyG), and related parameters (TyG-BMI, TyG-WC) with prehypertension and hypertension over 45 years old. According to the blood pressure diagnosis, the enrolled individuals were divided into two groups, which were prehypertension and hypertension. In multivariate logistic regression analysis, after adjusting for confounders, the highest quartile groups of TG/HDL-c, TyG, and related parameters showed a significantly increased risk of hypertension compared to the lowest quartile groups, and there was associated with hypertension when comparing the highest TG/HDL-c to the lowest TG/HDL-c and corresponding ORs were 1.
View Article and Find Full Text PDFAssociation between insulin resistance indices and kidney stones: results from the 2015-2018 National Health and Nutrition Examination Survey.
Front Nutr
October 2024
Department of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Objective: To explore the association between representative insulin resistance (IR) indices and the risk of kidney stone disease in an American adult population. The representative IR indices referred to metabolic score for IR (METS-IR), triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, triglyceride glucose-body mass index (TyG-BMI), visceral adiposity index (VAI), and homeostatic model assessment of IR (HOMA-IR).
Methods: We investigated adult participants who joined the 2015-2018 National Health and Nutrition Examination Survey (NHANES) and reported kidney stone histories.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!