AI Article Synopsis
- The inflammasome is a protein complex that plays a crucial role in the body's innate immune response and is involved in processes like inflammation, apoptosis, and metabolic diseases.
- There has been a rise in metabolic syndrome patients with insulin resistance (IR), linking the inflammasome to the development of type 2 diabetes mellitus (T2DM) and affecting insulin signaling pathways.
- This review covers the main types of inflammasomes (NLRP1, NLRP3, NLRC4, NLRP6, AIM2), their roles in IR, and discusses potential therapeutic options targeting the inflammasome for T2DM, particularly focusing on NLRP3-related treatments.
Article Abstract
The inflammasome is a protein complex composed of a variety of proteins in cells and which participates in the innate immune response of the body. It can be activated by upstream signal regulation and plays an important role in pyroptosis, apoptosis, inflammation, tumor regulation, etc. In recent years, the number of metabolic syndrome patients with insulin resistance (IR) has increased year by year, and the inflammasome is closely related to the occurrence and development of metabolic diseases. The inflammasome can directly or indirectly affect conduction of the insulin signaling pathway, involvement the occurrence of IR and type 2 diabetes mellitus (T2DM). Moreover, various therapeutic agents also work through the inflammasome to treat with diabetes. This review focuses on the role of inflammasome on IR and T2DM, pointing out the association and utility value. Briefly, we have discussed the main inflammasomes, including NLRP1, NLRP3, NLRC4, NLRP6 and AIM2, as well as their structure, activation and regulation in IR were described in detail. Finally, we discussed the current therapeutic options-associated with inflammasome for the treatment of T2DM. Specially, the NLRP3-related therapeutic agents and options are widely developed. In summary, this article reviews the role of and research progress on the inflammasome in IR and T2DM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040598 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1052756 | DOI Listing |
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