AI Article Synopsis
- Recent research has been looking into how our body's natural defense system, called innate immunity, works, especially focusing on two important molecules: interferon and Interleukin 6.
- These molecules send signals through special helpers called JAK and STAT.
- The review explores how the JAK/STAT system relates to certain muscle diseases and suggests that using JAK inhibitors might be helpful in treating them, especially for specific conditions like dermatomyositis and antisynthetase syndrome.
Article Abstract
In recent decades, several pieces of evidence have drawn greater attention to the topic of innate immunity, in particular, interferon (IFN) and Interleukin 6 in the pathogenesis of idiopathic inflammatory myopathies (IIM). Both of these molecules transduce their signal through a receptor coupled with Janus kinases (JAK)/signal transducer and activator of transcription proteins (STAT). In this review, we discuss the role of the JAK/STAT pathway in IIM, evaluate a possible therapeutic role for JAK inhibitors in this group of diseases, focusing on those with the strongest IFN signature (dermatomyositis and antisynthetase syndrome).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040547 | PMC |
| http://dx.doi.org/10.3389/fmed.2023.1158768 | DOI Listing |
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