Objective: The purpose of this research is to compare over the developing trend in Covid-19 research publications between 2020 and 2021 in India, overall in respect of age groups, health conditions, funding support, institutions, and research design.
Background: Covid-19 is a contagious disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV), first cited in Wuhan, China in December 2019. And has affected the entire world rapidly and still ongoing. The symptoms are fever, cough, weakness, and breathlessness; the infected individual develops pneumonia that sometimes leads to respiratory failure. The older population with co-morbidities is at higher risk.
Methodology: This is a cross-sectional study done by Scopus, Web of Science, and Pubmed Indexed journals, with the Covid-19, SARS-CoV, Pandemic, Coronavirus, India, and Outburst as keywords. Yearly publication data were extracted through 'Bibliometrix R studio' and relative percentage was computed and linear or exponential regressions examined the yearly growth in the proportion to research publications on Covid-19.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_1394_21 | DOI Listing |
J Med Chem
January 2025
Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany.
The main protease M is a clinically validated target to treat infections by the coronavirus SARS-CoV-2. Among the first reported M inhibitors was the peptidomimetic α-ketoamide , whose cocrystal structure with M paved the way for multiple lead-finding studies. We established structure-activity relationships for the series by modifying residues at the P1', P3, and P4 sites.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Faculty of Chemistry, Biotechnology and Food Science, NMBU - Norwegian University of Life Sciences, Ås, Norway.
Unlabelled: a natural inhabitant of the human body, is a promising candidate vehicle for vaccine delivery. An obstacle in developing bacterial delivery vehicles is generating a production strain that lacks antibiotic resistance genes and contains minimal foreign DNA. To deal with this obstacle, we have constructed a finetuned, inducible two-plasmid CRISPR/Cas9-system for chromosomal gene insertion in .
View Article and Find Full Text PDFJ Virol
January 2025
Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
The common cold coronaviruses are a source of ongoing morbidity and mortality particularly among elderly and immunocompromised individuals. While cross-reactive immune responses against multiple coronaviruses have been described following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, it remains unclear if these confer any degree of cross-protection against the common cold coronaviruses. A recombinant fowl adenovirus vaccine expressing the SARS-CoV-2 spike protein (FAdV-9-S19) was generated, and protection from SARS-CoV-2 challenge was shown in K18-hACE2 mice.
View Article and Find Full Text PDFHealth Promot Chronic Dis Prev Can
January 2025
Department of Psychology, University of Regina, Regina, Saskatchewan, Canada.
Introduction: This study provides a descriptive overview of the prevalence of posttraumatic stress disorder (PTSD) in Canada, across sociodemographic characteristics, mental health-related variables and negative impacts of the COVID-19 pandemic.
Methods: Data were obtained from cycles 1 and 2 of the Survey on COVID-19 and Mental Health (SCMH), collected in fall 2020 (N = 14 689) and spring 2021 (N = 8032). The prevalence of PTSD was measured using the PTSD Checklist for DSM-5 (PCL-5) Cross-sectional associations were quantified using logistic regression, while controlling for sociodemographic characteristics.
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