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Molecular Detection and Genetic Characterization of Japanese Encephalitis Virus in Animals from 11 Provinces in China. | LitMetric

AI Article Synopsis

  • Japanese encephalitis virus (JEV) poses risks to human and animal health, primarily transmitted by mosquitoes and found in swine and other mammals.
  • A study analyzed 3105 mammals and 17,300 mosquitoes across multiple regions in China, discovering JEV in pigs, goats, and mosquitoes, with the highest infection rates occurring in Heilongjiang.
  • The research also identified several mutations in the JEV envelope protein among infected animals, aiming to enhance understanding of the virus's molecular epidemiology and improve prevention efforts.

Article Abstract

Japanese encephalitis virus (JEV), which uses a mosquito primary vector and swine as a reservoir host, poses a significant risk to human and animal health. JEV can be detected in cattle, goats and dogs. A molecular epidemiological survey of JEV was conducted in 3105 mammals from five species, swine, fox, racoon dog, yak and goat, and 17,300 mosquitoes from 11 Chinese provinces. JEV was detected in pigs from Heilongjiang (12/328, 3.66%), Jilin (17/642, 2.65%), Shandong (14/832, 1.68%), Guangxi (8/278, 2.88%) and Inner Mongolia (9/952, 0.94%); in goats (1/51, 1.96%) from Tibet; and mosquitoes (6/131, 4.58%) from Yunnan. A total of 13 JEV envelope (E) gene sequences were amplified in pigs from Heilongjiang (5/13), Jilin (2/13) and Guangxi (6/13). Swine had the highest JEV infection rate of any animal species, and the highest infection rates were found in Heilongjiang. Phylogenetic analysis indicated that the predominant strain in Northern China was genotype I. Mutations were found at residues 76, 95, 123, 138, 244, 474 and 475 of E protein but all sequences had predicted glycosylation sites at 'N154. Three strains lacked the threonine 76 phosphorylation site from non-specific (unsp) and protein kinase G (PKG) site predictions; one lacked the threonine 186 phosphorylation site from protein kinase II (CKII) prediction; and one lacked the tyrosine 90 phosphorylation site from epidermal growth factor receptor (EGFR) prediction. The aim of the current study was to contribute to JEV prevention and control through the characterization of its molecular epidemiology and prediction of functional changes due to E-protein mutations.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051441PMC
http://dx.doi.org/10.3390/v15030625DOI Listing

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