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HPV E6/E7-Induced Acetylation of a Peptide Encoded by a Long Non-Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer.
Adv Sci (Weinh)
January 2025
Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing Medical University, Nanjing, 210004, P. R. China.
Although a fraction of functional peptides concealed within long non-coding RNAs (lncRNAs) is identified, it remains unclear whether lncRNA-encoded peptides are involved in the malignancy of cervical cancer (CC). Here, a 92-amino acid peptide is discovered, which is named TUBORF, encoded by lncRNA TUBA3FP and highly expressed in CC tissues. TUBORF inhibits ferroptosis to promote the malignant proliferation of CC cells.
View Article and Find Full Text PDFSmall protein ERSP encoded by LINC02870 promotes triple negative breast cancer progression via IRE1α/XBP1s activation.
Cell Death Differ
January 2025
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.
Clinical treatment options for triple-negative breast cancer (TNBC) are currently limited to chemotherapy because of a lack of effective therapeutic targets. Recent evidence suggests that long noncoding RNAs (lncRNAs) encode bioactive peptides or proteins, thereby playing noncanonical yet significant roles in regulating cellular processes. However, the potential of lncRNA-translated products in cancer progression remains largely unknown.
View Article and Find Full Text PDFMicropeptides derived from long non-coding RNAs: Computational analysis and functional roles in breast cancer and other diseases.
Gene
January 2025
Institute of Chinese Medicine Surgery, Anhui Academy of Chinese Medicine, Hefei 230031, China. Electronic address:
Long non-coding RNAs (lncRNAs), once thought to be mere transcriptional noise, are now revealing a hidden code. Recent advancements like ribosome sequencing have unveiled that many lncRNAs harbor small open reading frames and can potentially encode functional micropeptides. Emerging research suggests these micropeptides, not the lncRNAs themselves, play crucial roles in regulating homeostasis, inflammation, metabolism, and especially in breast cancer progression.
View Article and Find Full Text PDFLncPepAtlas: a comprehensive resource for exploring the translational landscape of long non-coding RNAs.
Nucleic Acids Res
January 2025
Binzhou People's Hospital Affiliated to Shandong First Medical University/College of Medical Information and Artificial Intelligence, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China.
Long non-coding RNAs were commonly viewed as non-coding elements. However, they are increasingly recognized for their ability to be translated into proteins, thereby playing a significant role in various cellular processes and diseases. With developments in biotechnology and computational algorithms, a range of novel approaches are being applied to investigate the translation of long non-coding RNA (lncRNAs).
View Article and Find Full Text PDFCircRNA and lncRNA-encoded peptide in diseases, an update review.
Mol Cancer
September 2024
Department of Orthopedics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, 518035, China.
Article Synopsis
- - Non-coding RNAs (ncRNAs), like circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), are important RNA molecules found in eukaryotic genomes and are linked to various diseases, particularly cancers, due to their dysregulation.
- - Recent studies show that some ncRNAs contain open reading frames (ORFs) that allow them to code for proteins or peptides, which play significant roles in physiological and pathological processes.
- - This review provides an overview of the proteins/peptides produced by lncRNAs and circRNAs, discussing their mechanisms and potential applications in cancer diagnosis, disease prediction, and targeted therapies.
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