AI Article Synopsis
- Understanding the duration of measles immunity from both maternal sources and vaccinations is important for future immunization strategies.
- Research shows that immunity from mothers lasts about 2.4 months, while immunity from the measles-containing vaccine (MCV) decreases significantly after around 14 years.
- Administering a catch-up MCV dose can dramatically lower the chances of losing immunity by 79.3-88.7% in children by age 6, indicating the need for adjustments in vaccination schedules.
Article Abstract
Characterizing the long-term kinetics of maternally derived and vaccine-induced measles immunity is critical for informing measles immunization strategies moving forward. Based on two prospective cohorts of children in China, we estimate that maternally derived immunity against measles persists for 2.4 months. Following two-dose series of measles-containing vaccine (MCV) at 8 and 18 months of age, the immune protection against measles is not lifelong, and antibody concentrations are extrapolated to fall below the protective threshold of 200 mIU/ml at 14.3 years. A catch-up MCV dose in addition to the routine doses between 8 months and 5 years reduce the cumulative incidence of seroreversion by 79.3-88.7% by the age of 6 years. Our findings also support a good immune response after the first MCV vaccination at 8 months. These findings, coupled with the effectiveness of a catch-up dose in addition to the routine doses, could be instrumental to relevant stakeholders when planning routine immunization schedules and supplemental immunization activities.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054217 | PMC |
| http://dx.doi.org/10.1038/s41467-023-37407-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!