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Trans-Coronary Sinus Intra-Septal Radiofrequency Ablation (TIRA) for Hypertrophic Obstructive Cardiomyopathy: First-in-Human Results.
Biomedicines
December 2024
Department of Internal Medicine, Pusan National University School of Medicine and Cardiology, Cardiovascular Center and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.
Background: Current treatments for hypertrophic obstructive cardiomyopathy (HOCM), including medication, surgery, and alcohol septal ablation (ASA), have limitations in terms of efficacy and safety. To address these challenges, we developed the trans-coronary intra-septal radiofrequency ablation (TIRA) device.
Methods: This first-in-human trial was conducted to assess the efficacy and safety of the TIRA device.
Recurrent atrial flutter after radiofrequency ablation for atrial fibrillation in a patient with hypertrophic obstructive cardiomyopathy undergoing repetitive transcoronary ablation of septal hypertrophy.
BMC Cardiovasc Disord
October 2024
Department of Cardiology, Songshan General Hospital, 69 Xingguang Street, Chongqing, 401120, China.
Article Synopsis
- The case study focuses on a 71-year-old woman with hypertrophic obstructive cardiomyopathy (HOCM) who experienced multiple arrhythmias and complications, including atrial flutter after her treatments.
- Initially diagnosed with HOCM based on echocardiography, she underwent two transcoronary ablations of septal hypertrophy, with varying success, and later developed atrial fibrillation which required further intervention.
- The findings support that while the treatment of HOCM can be complicated by arrhythmias, a combination of catheter ablation and targeted therapies can lead to positive long-term outcomes for patients.
Transcoronary guidewire ablation with radiofrequency in a porcine animal model.
J Invasive Cardiol
August 2024
Department of Medicine III, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Objectives: Transcoronary ablation of septal hypertrophy (TASH) and surgical myectomy are the recommended treatment options for patients with hypertrophic obstructive cardiomyopathy refractory (HOCM) when conventional drug treatment is not sufficient. We describe the application of radiofrequency (RF) energy via coronary guidewires in an animal model for selective occlusion of coronary side branches that mimics the principle of TASH.
Methods: Transcoronary guidewire ablation of coronary vessels was performed in 5 adult pigs under general anaesthesia in an animal cathlab after successful bench testing of the ablation settings.
Concomitant treatment of sustained ventricular tachycardia and hypertrophic cardiomyopathy with transcoronary ethanol ablation: a case report.
Eur Heart J Case Rep
January 2024
Department of Cardiology, University of Chicago Northshore University Health Systems, 2650 Ridge Avenue, Evanston, IL 60201, USA.
Background: The recommended treatment for recurrent ventricular tachycardia in patients with hypertrophic cardiomyopathy that is not amenable to defibrillator implantation due to shock burden is radiofrequency ablation. In patients with deeply intramural foci of ventricular tachycardia, traditional unipolar ablation has a lower probability of success.
Case Summary: A 66-year-old Caucasian man was admitted with ventricular tachycardia, which recurred despite antiarrhythmic drugs.
Transcoronary radiofrequency ablation for obstructive hypertrophic cardiomyopathy: a feasibility study.
Eur Heart J
January 2024
Department of Cardiology, Guizhou Provincial People's Hospital, 83 Zhongshan East Road, Guiyang 550002, China.
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