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NaHS restores the vascular alterations in the renin-angiotensin system induced by hyperglycemia in rats. | LitMetric

AI Article Synopsis

  • Hyperglycemia affects the renin-angiotensin system (RAS), leading to issues with blood vessel function, and hydrogen sulfide (HS) can have positive effects on cardiovascular health in metabolic diseases.
  • The study involved male diabetic rats that underwent treatment with sodium hydrosulfide (NaHS) and DL-Propargylglycine (DL-PAG) to assess their impacts on vascular responses associated with RAS after hyperglycemia.
  • The findings revealed that NaHS effectively improved vascular function in the diabetic rats by modulating the RAS, while DL-PAG did not have the same positive effects, highlighting the potential therapeutic role of NaHS in managing vascular dysfunction related to hyperglycemia.

Article Abstract

Hyperglycemia (HG) impairs the renin-angiotensin system (RAS), which may contribute to vascular dysfunction. Besides, hydrogen sulfide (HS) exerts beneficial cardiovascular effects in metabolic diseases. Therefore, our study aimed to determine the effects of chronic administration of sodium hydrosulfide (NaHS; inorganic HS donor) and DL-Propargylglycine [DL-PAG; cystathionine-ץ-lyase (CSE) inhibitor] on the RAS-mediated vascular responses impairments observed in thoracic aortas from male diabetic Wistar rats. For that purpose, neonatal rats were divided into two groups that received: 1) citrate buffer (n = 12) or 2) streptozotocin (STZ, 70 mg/kg; n = 48) on the third postnatal day. After 12 weeks, diabetic animals were divided into 4 subgroups (n = 12 each) that received daily i.p. injections during 4 weeks of: 1) non-treatment; 2) vehicle (PBS, 1 mL/kg); 3) NaHS (5.6 mg/kg); and 4) DL-PAG (10 mg/kg). After treatments (16 weeks), blood glucose, angiotensin-(1-7) [Ang-(1-7)], and angiotensin II (Ang II) levels, vascular responses to Ang-(1-7) and Ang II, and the expression of angiotensin AT, AT, and Mas receptors, angiotensin converting enzyme (ACE) and ACE type 2 (ACE2) were determined. HG induced: 1) increased blood glucose levels and expression of angiotensin II AT receptor; 2) impaired Ang-(1-7) and Ang II mediated vascular responses; 3) decreased angiotensin levels and expression of angiotensin II AT and angiotensin-(1-7) Mas receptors, and ACE2; and 4) no changes in ACE expression. Interestingly, NaHS, but not DL-PAG, reversed HG-induced impairments, except for blood glucose level changes. These results suggest that NaHS restores vascular function in streptozotocin-induced HG through RAS modulation.

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Source
http://dx.doi.org/10.1016/j.peptides.2023.171001DOI Listing

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