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| http://dx.doi.org/10.1002/mdc3.13604 | DOI Listing |
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The value of quantitative susceptibility mapping and morphometry in the differential diagnosis of Parkinsonism.
AJNR Am J Neuroradiol
January 2025
From the Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin Province, China.
Background And Purpose: Differentiating Parkinson's Disease (PD) from Atypical Parkinsonism Syndrome (APS), including Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP), is challenging, and there is no gold standard. Integrating quantitative susceptibility mapping (QSM) and morphometry can help differentiate PD from APS and improve the internal diagnosis of APS.
Materials And Methods: In this retrospective study, we enrolled 55 patients with PD, 17 with MSA-parkinsonian type (MSA-P), 15 with MSA-cerebellar type (MSA-C), and 14 with PSP.
Assisted Parkinsonism Diagnosis Using Multimodal MRI-The Role of Clinical Insights.
Brain Behav
January 2025
Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Background: While automated methods for differential diagnosis of parkinsonian syndromes based on MRI imaging have been introduced, their implementation in clinical practice still underlies considerable challenges.
Objective: To assess whether the performance of classifiers based on imaging derived biomarkers is improved with the addition of basic clinical information and to provide a practical solution to address the insecurity of classification results due to the uncertain clinical diagnosis they are based on.
Methods: Retro- and prospectively collected data from multimodal MRI and standardized clinical datasets of 229 patients with PD (n = 167), PSP (n = 44), or MSA (n = 18) underwent multinomial classification in a benchmark study comparing the performance of nine machine learning methods.
Idiopathic normal pressure hydrocephalus concomitant with progressive supranuclear palsy.
Parkinsonism Relat Disord
January 2025
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address:
Introduction: Recent studies by us and others have unveiled a frequent coexistence of idiopathic normal pressure hydrocephalus (iNPH) with neurodegenerative movement disorders, including progressive supranuclear palsy (PSP). This study aims to explore the clinical and radiological characteristics of patients with iNPH who also had comorbid with PSP, referred to as iNPHc + PSP.
Methods: We retrospectively analyzed patients with iNPH admitted to our department between 2009 and 2024.
Splenomegaly and progressive neurologic involvement: Think about Niemann-Pick type C disease.
Pediatr Int
December 2024
Medical Faculty, Department of Pediatric Metabolism and Nutrition, Ege University, Izmir, Türkiye.
Background: Niemann-Pick type C (NPC) disease is a lysosomal storage disease with visceral organ involvement and neurological and psychiatric symptoms. This study presents the clinical and laboratory findings of NPC cases involving three novel variants.
Methods: The clinical and laboratory findings were reviewed retrospectively between February 2006 and December 2022.
Video-oculography for enhancing the diagnostic accuracy of early oculomotor dysfunction in Progressive Supranuclear Palsy.
J Mov Disord
December 2024
Parkinson and Movement Disorder Centre, Department of Neurology, Aster Medcity, Kochi, Kerala, India.
Background: Oculomotor impairment is an important diagnostic feature of Progressive Supranuclear Palsy (PSP) and PSP subtypes.
Objectives: We assessed the role of video oculography (VOG) in confirming clinically suspected slow saccades in PSP and differentiating PSP from Parkinson's disease (PD). We also measured the correlation of both saccadic velocity and latency in PSP with scores in PSP rating scale, Montreal Cognitive Assessment (MoCA) and Frontal assessment battery (FAB).
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