The aim of this study was to identify propolis compounds after incubation of normal and tumor cells (monocytes and HEp-2 cells, respectively) with Brazilian green propolis, in the lysate and supernatant of cell cultures and within these cells by gas chromatography-mass spectrometry (GC/MS). Cinnamic acid derivatives were generally localized in the lysate of both cell lines after incubation, suggesting these compounds are actively transported across the membrane into the cytoplasm. Terpenes were also found in the lysate. Artepillin C, in contrast, was localised only in the supernatant. Some constituents were unobservable after incubation, especially in monocytes, suggesting the compounds had been degraded. Our findings shed light on the possible sites of action (intracellular or via a cell membrane protein) and the bioavailability of various constituents of propolis, as well as possible modes of delivery of bioactive constituents.
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http://dx.doi.org/10.1002/cbdv.202300348 | DOI Listing |
Forensic Sci Int
January 2025
Departamento de Química. Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Universidade de São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto, São Paulo CEP 14040-901, Brazil; Instituto Nacional de Ciência e Tecnologia Ciências Forenses (INCT-Forense), Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14040-901, Brasil; Programa de Cooperação Acadêmica - Segurança Pública e Ciências Forenses (PROCAD-SPCF), Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14040-901, Brasil. Electronic address:
Forensic gemstone analysis faces many challenges. One of the most critical aspects of gemological research is the classification of a gemstone. It is necessary to understand the mineral species, purity, origin, and identification of treatments to identify and classify a gem correctly, as well as assign a monetary value to it.
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January 2025
Departamento de genética, ecologia e evolução, Laboratório de biologia integrativa, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Background: The angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are central human molecules in the SARS-CoV-2 virus-host interaction. Evidence indicates that may influence expression. This study aims to determine whether ACE1, ACE2, and TMPRSS2 mRNA expression levels, along with the ACE1 Alu 287 bp polymorphism (rs4646994), contribute to the severity and mortality of COVID-19.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Psychology, Department of Cognition, Emotion, and Methods in Psychology, University of Vienna, Vienna, Austria.
The Satisfaction With Life Scale (SWLS) is a widely used self-report measure of subjective well-being, but studies of its measurement invariance across a large number of nations remain limited. Here, we utilised the Body Image in Nature (BINS) dataset-with data collected between 2020 and 2022 -to assess measurement invariance of the SWLS across 65 nations, 40 languages, gender identities, and age groups (N = 56,968). All participants completed the SWLS under largely uniform conditions.
View Article and Find Full Text PDFAesthetic Plast Surg
January 2025
Division of Plastic Surgery, Federal University of São Paulo, Rua Botucatu, 740-2º andar, Vila Clementino, São Paulo, SP, Brazil.
Introduction: Rib resection and remodeling have gained attention as cosmetic procedures to enhance body contours, particularly waist-to-hip ratio. Historically, rib resection has been used for medical reasons; however, plastic surgeons have recently adopted it for aesthetic purposes. However, concerns remain regarding the safety and effectiveness of the procedure, particularly due to the potential for complications, such as pneumothorax, chronic pain, and impaired respiratory function.
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January 2025
School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14440-903, Brazil.
The demand for food production has been growing exponentially due to the increase in the global population. Innovative approaches to enhance agricultural productivity have been explored, including the new applications of nanoparticles in agriculture. The nanoparticle application in agriculture can generate environmental and human health risks since nanoparticles can contaminate the soil and inevitably reach groundwater, potentially causing toxicity in aquatic organisms.
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