Current cancer treatments damage healthy cells and tissues, causing short-term and long-term side effects. New treatments are desired that show greater selectivity toward cancer cells and evade the common mechanisms of multidrug resistance. Membranolytic anticancer peptides (mACPs) hold promise against cancer and multidrug resistance. Amphipathicity, hydrophobicity, and net charge of mACPs participate in their respective interactions with cell membranes and their overall inhibition of cancer cells. To support the design of cell-line selective mACPs, we investigated the relationships that amino acid composition, physicochemical properties, sequence motifs, and sequence homology could have with their potency and selectivity towards several healthy and cancer cell lines. Sequence length and net charge are known to affect the selectivity of mACPs between cancer and healthy cell lines. Our study reveals that increasing the net charge or flexibility (i. e., small and aliphatic residues) influences their selectivity between cancer cell lines with comparable lipid compositions.
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http://dx.doi.org/10.1002/cbic.202300058 | DOI Listing |
ACS Omega
January 2025
Department of Applied Chemistry, ZHCET, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India.
Herein, we have synthesized a Co(II)-based 2D coordination polymer [Co(5-AIA)(Imidazole)] () (AIA = 5-aminoisophthalic acid) via a solvothermal approach. SCXRD (single-crystal X-ray diffraction) was utilized to analyze the crystal structure of fabricated . Moreover, PXRD, TGA, FTIR, and SEM analyses were done to identify the structural features of fabricated .
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
City University of Hong Kong, Materials Science and Engineering, 83 Tat Chee Ave., Kowloon, HONG KONG.
Recently, aqueous proton batteries have shown promise for electrochemical energy storage using MXene electrodes. However, designing high-performance MXene proton batteries remains challenging due to the inevitable hydrogen evolution reaction (HER), the vast chemical composition space of MXene, and the unclear proton transport mechanism. To tackle these challenges, we established a general descriptor based on structural units of MXenes, termed the octahedral net charge descriptor (Qoct).
View Article and Find Full Text PDFSci Adv
January 2025
Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano and IU.NET, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
Neurological disorders are a substantial global health burden, affecting millions of people worldwide. A key challenge in developing effective treatments and preventive measures is the realization of low-power wearable systems with early detection capabilities. Traditional strategies rely on machine learning algorithms, but their computational demands often exceed what miniaturized systems can provide.
View Article and Find Full Text PDFBiotechnol J
January 2025
School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, Ireland.
Adeno-associated virus (AAV) is a versatile viral vector technology that can be engineered for specific functionality in vaccine and gene therapy applications. One of the major challenges in AAV production is the need for a GMP-ready platform-based approach to downstream processing, as this would lead to a standardized method for multiple products. Chromatography has huge potential in AAV purification, as it is a scalable method that would enable manufacturing to a high degree of purity, potency, and consistency.
View Article and Find Full Text PDFJ Phys Chem B
January 2025
Department of Chemistry, Kansas State University, Manhattan, Kansas 66506, United States.
Ion atmospheres play a critical role in modulating the interactions between charged components in solutions. However, a detailed description of the nature of ion atmospheres remains elusive. Here, we use Kirkwood-Buff theory, an exact theory of solution mixtures, together with a series of local and bulk electroneutrality constraints to provide relationships between all the net ion-ion distributions in bulk electrolyte mixtures.
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