Rare Vulvar Angiomyofibroblastoma: Case Series and Literature Review.

Int J Womens Health

Department of Ultrasound Medicine, Affiliated Hospital of Jiangnan University, Wuxi City, Jiangsu Province, People's Republic of China.

Published: March 2023

Background: Angiomyofibroblastoma (AMFB) is an uncommon disease with few literature reports, leading to the poor understanding of its diagnosis, treatment, and postoperative follow-up plans among gynecologists.

Objective: To study the clinical and pathological features of vulvar AMFB and discuss its treatment and prognosis.

Case Summary: The 3 cases were characterized by a gradually increasing painless mass in the vulva. Preoperative diagnosis was difficult and mainly depended on ultrasonic examination. Immunohistochemistry confirmed clear boundaries of AMFB. This condition could be completely cured by surgery, and the prognosis was good.

Conclusion: The vulvar AMFB is a rare tumor that is frequently misdiagnosed before surgery. Ultrasound is preferred in auxiliary diagnosis, and surgery remains the best treatment, and long-term follow-up is necessary to avoid recurrence or other complications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040152PMC
http://dx.doi.org/10.2147/IJWH.S403121DOI Listing

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Article Synopsis
  • - Angiomyofibroblastoma (AMFB) is a very rare benign tumor found in the lower genital tract, mainly affecting premenopausal women and usually requires surgical removal.
  • - A unique case involved a 51-year-old woman with breast cancer who had a large pelvic mass, which turned out to be AMFB in the uterus, confirmed through histopathology and immunohistochemical analysis.
  • - This case emphasizes the need for accurate diagnosis of AMFB, as it can mimic other tumors like aggressive angiomyxoma, and suggests potential connections with uterine myomas that need further research.
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Angiomyofibroblastoma of the vulva: A case report and review of the literature.

Case Rep Womens Health

June 2024

Department of Obstetrics and Gynecology, Oncology and High-Risk Pregnancies, Maternity Hospital Souissi, Ibn Sina Teaching Hospital, University Mohammed V, 12000 Rabat, Morocco.

Angiomyofibroblastoma (AMFB) represents a rare, benign mesenchymal tumor with a predilection for the vulvovaginal region. It is usually diagnosed in middle-aged women. Histopathology and immunohistochemical study remain the key to diagnosis.

View Article and Find Full Text PDF

Rare Vulvar Angiomyofibroblastoma: Case Series and Literature Review.

Int J Womens Health

March 2023

Department of Ultrasound Medicine, Affiliated Hospital of Jiangnan University, Wuxi City, Jiangsu Province, People's Republic of China.

Background: Angiomyofibroblastoma (AMFB) is an uncommon disease with few literature reports, leading to the poor understanding of its diagnosis, treatment, and postoperative follow-up plans among gynecologists.

Objective: To study the clinical and pathological features of vulvar AMFB and discuss its treatment and prognosis.

Case Summary: The 3 cases were characterized by a gradually increasing painless mass in the vulva.

View Article and Find Full Text PDF

Introduction Mesenchymal tumors of the lower female genital tract (FGT) are a miscellaneous group of tumors that include aggressive angiomyxoma (AAM), angiomyofibroblastoma (AMFB), cellular angiofibroma (CAF), and related entities. Histologically, these tumors are composed of stromal cells admixed with vessels, with some minor histological differences. An accurate diagnosis of these tumors is important owing to the differences in the outcome.

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Mesenchymal tumours of the vulva are rare and consist of two types, difficult to distinguish but with different prognoses. Angiomyofibroblastoma (AMFB) is a benign tumour, whereas Aggressive Angiomyxoma (AA) is an infiltrating tumour. We describe a 22-year-old nulliparous patient with a vulvar mass sized 19 cm in diameter.

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