AI Article Synopsis
- A total of 21 new xanthone and acridone compounds were created through specific chemical reactions involving triazine derivatives and acridone/xanthone derivatives, followed by optional ring aromatization.
- Five of these compounds showed promising anticancer effects against several types of cancer cells, including colorectal and glioblastoma.
- Notably, certain compounds exhibited low toxicity to normal kidney cells, indicating their potential for further development as cancer treatments, with one compound activating apoptotic mechanisms in glioblastoma cells.
Article Abstract
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring aromatization. The synthesized compounds were evaluated for their anticancer activity against colorectal cancer HCT116, glioblastoma A-172, breast cancer Hs578T, and human embryonic kidney HEK-293 tumor cell lines. Five compounds (, , , , and ) displayed good in vitro antiproliferative activities against these cancer cell lines. Compounds and demonstrated low toxicity for normal human embryonic kidney (HEK-293) cells, which determines the possibility of further development of these compounds as anticancer agents. Annexin V assay demonstrated that compound activates apoptotic mechanisms and inhibits proliferation in glioblastoma cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058176 | PMC |
| http://dx.doi.org/10.3390/ph16030403 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!