AI Article Synopsis
- Lung conditions like COPD and risk factors such as alcohol misuse and smoking can worsen COVID-19 severity by impacting immunity.
- A study found that short exposure to alcohol or cigarette smoke extract increased SARS-CoV-2 viral levels and lung cell injury in COPD patients' cells.
- The combination of these factors led to higher IL-8 secretion, indicating increased inflammation and impaired lung defenses in COPD patients against COVID-19.
Article Abstract
Lung conditions such as COPD, as well as risk factors such as alcohol misuse and cigarette smoking, can exacerbate COVID-19 disease severity. Synergistically, these risk factors can have a significant impact on immunity against pathogens. Here, we studied the effect of a short exposure to alcohol and/or cigarette smoke extract (CSE) in vitro on acute SARS-CoV-2 infection of ciliated human bronchial epithelial cells (HBECs) collected from healthy and COPD donors. We observed an increase in viral titer in CSE- or alcohol-treated COPD HBECs compared to untreated COPD HBECs. Furthermore, we treated healthy HBECs accompanied by enhanced lactate dehydrogenase activity, indicating exacerbated injury. Finally, IL-8 secretion was elevated due to the synergistic damage mediated by alcohol, CSE, and SARS-CoV-2 in COPD HBECs. Together, our data suggest that, with pre-existing COPD, short exposure to alcohol or CSE is sufficient to exacerbate SARS-CoV-2 infection and associated injury, impairing lung defences.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056639 | PMC |
| http://dx.doi.org/10.3390/pathogens12030498 | DOI Listing |
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