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Combined Toxicity of the Most Common Indoor Aspergilli. | LitMetric

Combined Toxicity of the Most Common Indoor Aspergilli.

Pathogens

Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia.

Published: March 2023

AI Article Synopsis

Article Abstract

The most common Aspergilli isolated from indoor air samples from occupied buildings and a grain mill were extracted and analyzed for their combined ( + , + ) cytotoxic, genotoxic and pro-inflammatory properties on human adenocarcinoma cells (A549) and monocytic leukemia cells induced in macrophages (THP-1 macrophages). Metabolite mixtures from the Aspergilli series increase the cytotoxic and genotoxic potency of extracts in A549 cells suggesting additive and/or synergistic effects, while antagonizing the cytotoxic potency of extracts in THP-1 macrophages and genotoxicity in A549 cells. All tested combinations significantly decreased IL-5 and IL-17, while IL-1β, TNF-α and IL-6 relative concentrations were increased. Exploring the toxicity of extracted Aspergilli deepens the understanding of intersections and interspecies differences in events of chronic exposure to their inhalable mycoparticles.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058518PMC
http://dx.doi.org/10.3390/pathogens12030459DOI Listing

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