Rotenoids and Isoflavones from (Taub.) Mendonça & E.P. Souza and Their Biological Activities.

The phytochemical study of the ethanolic extract of the leaf of led to the isolation of five hitherto unreported compounds including two isoflavones (-), and three rotenoids (-), along with eight known isoflavonoid derivatives (-) and one pterocarpan derivative (). The structures of the new compounds and those of the known ones were established by the spectroscopic (1D and 2D NMR) and spectrometric (HRESIMS) techniques as well as a comparison of their spectroscopic data with those reported in the literature. The leaf extract, fractions, and isolated compounds were tested for their antibacterial effects against nine bacterial strains. Compounds , , and showed a significant antibacterial effect, with a minimum inhibitory concentration (MIC) value of 62.5 µg/mL each, against , , , and , respectively. In addition, the leaf extract, fractions, and isolated compounds were tested for their antifungal effects against four fungal strains. The hexane fraction showed a significant antifungal effect with an MIC value of 125 µg/mL against , whereas compounds , , and showed significant antifungal activity with an MIC value of 62.5 µg/mL, each against , , and , respectively.