Three novel compounds () along with twenty-six known compounds, two known steroids () and twenty-four known phenylpropanoids () were isolated from the whole plant of Turcz. The structures of the three new compounds were elucidated on the basis of ESI-MS, HR-ESIMS, 1D and 2D NMR, IR, UV spectroscopic data. The absolute stereochemistry of compound was determined by the Gauge-Including Atomic Orbitals (GIAO) method. The in vitro antioxidant, anti-inflammatory and cytotoxic activities of the isolated compounds were evaluated by DPPH radical-scavenging assay, LPS-activated RAW 264.7 cells model and CCK-8 kit, respectively. Compound showed high antioxidant activity with an SC value of 16.2 ± 1.6 μM. Compound showed considerable anti-inflammatory activity with an IC value of 28.6 ± 3.0 μM. Compounds and displayed potent cytotoxic activity against human NCI-H292, SiHa, A549, and MKN45 cell lines, with the compound having IC values of 17.4 ± 2.4, 22.2 ± 1.1, 9.7 ± 0.9, 9.5 ±0.7 μM, and the compound having all IC values less than 0.1 μM in vitro.
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| http://dx.doi.org/10.3390/molecules28062685 | DOI Listing |
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