AI Article Synopsis
- * Py-2-C is significant in diabetes research, as its derivative pyrraline serves as a molecular marker related to the disease.
- * The review details the origins, structural features, and biological activities of Py-2-C derivatives, emphasizing their potential roles in health and disease.
Article Abstract
Pyrrole-2-carboxaldehyde (Py-2-C) derivatives have been isolated from many natural sources, including fungi, plants (roots, leaves, and seeds), and microorganisms. The well-known diabetes molecular marker, pyrraline, which is produced after sequential reactions in vivo, has a Py-2-C skeleton. Py-2-Cs can be chemically produced by the strong acid-catalyzed condensation of glucose and amino acid derivatives in vitro. These observations indicate the importance of the Py-2-C skeleton in vivo and suggest that molecules containing this skeleton have various biological functions. In this review, we have summarized Py-2-C derivatives based on their origins. We also discuss the structural characteristics, natural sources, and physiological activities of isolated compounds containing the Py-2-C group.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058459 | PMC |
| http://dx.doi.org/10.3390/molecules28062599 | DOI Listing |
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