Constituents of the Stem Bark of Linn. f. with Antileishmanial and Antibacterial Activities.

The chemical investigation of the -hexane fraction from the methanol extract of the stem bark of Linn f., which displayed good in vitro activity against NR-48822 promastigotes (IC 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U (), V ()/W (), and a new tocotrienol derivative named globuliferanol (), along with 11 known compounds (-). Their structures were elucidated based on their NMR and MS data. Some isolated compounds were assessed for both their antileishmanial and cytotoxic activities against and Vero cells, respectively. Guttiferone K () exhibited the best potency (IC 3.30 μg/mL), but with low selectivity to Vero cells. The -hexane fraction and some compounds were also assessed in vitro for their antibacterial activity against seven bacterial strains. All the samples exhibited moderate to potent antibacterial activity (MICs ≤ 15.6 µg/mL) against at least one of the tested strains.