AI Article Synopsis
- Some monoclonal antibodies (mAbs) have been found to be effective against fungal infections, indicating that antibody immunity may play a vital role in defending hosts from these infections.
- This discovery opens up the potential for creating vaccines that stimulate protective antibody immunity, which can enhance the immune response from both non-specific and specific immune cells.
- Future efforts will focus on developing these vaccines and understanding how antibodies provide protection against fungal infections.
Article Abstract
The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise to the possibility of developing vaccinations that trigger protective antibody immunity. These vaccines might work by inducing antibody opsonins that improve the function of non-specific (such as neutrophils, macrophages, and NK cells) and specific (such as lymphocyte) cell-mediated immunity and stop or aid in eradicating fungus infections. The ability of antibodies to defend against fungi has been demonstrated by using monoclonal antibody technology to reconsider the function of antibody immunity. The next step is to develop vaccines that induce protective antibody immunity and to comprehend the mechanisms through which antibodies mediate protective effects against fungus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051215 | PMC |
| http://dx.doi.org/10.3390/microorganisms11030671 | DOI Listing |
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