Milk thistle ( (L.) Gaertn.) is among the top-selling botanicals used as a supportive treatment for liver diseases. Silymarin, a mixture of unique flavonolignan metabolites, is the main bioactive component of milk thistle. The biological activities of silymarin have been well described in the literature, and its use is considered safe and well-tolerated in appropriate doses. However, commercial preparations do not always contain the recommended concentrations of silymarin, failing to provide the expected therapeutic effect. While the poor quality of raw material may explain the low concentrations of silymarin, its deliberate removal is suspected to be an adulteration. Toxic contaminants and foreign matters were also detected in milk thistle preparations, raising serious health concerns. Standard methods for determination of silymarin components include thin-layer chromatography (TLC), high-performance thin-layer chromatography (HPTLC), and high-performance liquid chromatography (HPLC) with various detectors, but nuclear magnetic resonance (NMR) and ultra-high-performance liquid chromatography (UHPLC) have also been applied. This review surveys the extraction techniques of main milk thistle metabolites and the quality, efficacy, and safety of the derived food supplements. Advanced analytical authentication approaches are discussed with a focus on DNA barcoding and metabarcoding to complement orthogonal chemical characterization and fingerprinting of herbal products.
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| http://dx.doi.org/10.3390/metabo13030440 | DOI Listing |
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Article Synopsis
- Silymarin, a flavonoid from milk thistle, shows promising effects like antioxidant and anti-inflammatory properties, particularly in cancer research.
- In a study on SPC212 human mesothelioma cells, silymarin was found to have a dose-dependent cytotoxic effect, with a half-maximal inhibitory concentration (IC) of about 187.5 µM.
- The compound induced signs of apoptosis, such as cell shrinkage and nuclear changes, suggesting its potential as an anti-cancer agent that needs further investigation.
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