AI Article Synopsis
- The authors found that the transdermal therapeutic system (TTS) for the immunomodulator ADPS provides similar drug absorption as intramuscular injections, but with lower peak blood levels and extended duration in the body.
- The study aimed to explore whether this transdermal method could enhance liver regeneration after extensive liver resection (ELR).
- Results showed that 48 hours after ELR, the ADPS TTS significantly increased liver cell activity and improved recovery rates in rats compared to the control group by 72 hours post-surgery.
Article Abstract
Previously, the authors showed that the application of the aminodihydrophthalazinedione sodium (ADPS) immunomodulator transdermal therapeutic system (TTS) to laboratory animals provides bioavailability analogous to the intramuscular administration of this drug at the same dose. At the same time, its maximum blood concentration is significantly reduced, and the retention time of the drug in the body is increased more than 10-fold, which can contribute to prolonging the drug effect. The aim of the work was to identify a possible positive effect of the transdermal administration of the ADPS immunomodulator on reparative liver regeneration on an experimental model of extensive liver resection (ELR). It has been shown that at a period of 48 h after ELR, the percutaneous administration of the immunomodulator has a pronounced stimulating effect on the mitotic activity of rat liver cells; by 72 h after ELR, an accelerated rate of recovery of hepatic homeostasis in the body was observed in laboratory animals in groups with the application of the ADPS TTS versus the control group.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051983 | PMC |
| http://dx.doi.org/10.3390/life13030658 | DOI Listing |
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Article Synopsis
- The authors found that the transdermal therapeutic system (TTS) for the immunomodulator ADPS provides similar drug absorption as intramuscular injections, but with lower peak blood levels and extended duration in the body.
- The study aimed to explore whether this transdermal method could enhance liver regeneration after extensive liver resection (ELR).
- Results showed that 48 hours after ELR, the ADPS TTS significantly increased liver cell activity and improved recovery rates in rats compared to the control group by 72 hours post-surgery.
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