AI Article Synopsis
- DIPG has a very poor prognosis, with less than 10% of patients surviving two years despite radiation therapy.
- Previous research indicates that DIPG cells are sensitive to low-intensity electric fields, prompting exploration of endoscopic endonasal implantation of electrode arrays for treatment.
- The study at Boston Children's Hospital shows that the anatomy of pediatric patients is suitable for 94% of them to receive a 2 × 1 cm electrode array, suggesting that implantable devices for tumor-treating fields may be feasible as a new therapy for DIPG.
Article Abstract
Diffuse intrinsic pontine glioma (DIPG) carries an extremely poor prognosis, with 2-year survival rates of <10% despite the maximal radiation therapy. DIPG cells have previously been shown to be sensitive to low-intensity electric fields in vitro. Accordingly, we sought to determine if the endoscopic endonasal (EE) implantation of an electrode array in the clivus would be feasible for the application of tumor-treating fields (TTF) in DIPG. Anatomic constraints are the main limitation in pediatric EE approaches. In our Boston Children's Hospital's DIPG cohort, we measured the average intercarotid distance (1.68 ± 0.36 cm), clival width (1.62 ± 0.19 cm), and clival length from the base of the sella (1.43 ± 0.69 cm). Using a linear regression model, we found that only clival length and sphenoid pneumatization were significantly associated with age (R = 0.568, = 0.005 *; R = 0.605, = 0.0002 *). Critically, neither of these parameters represent limitations to the implantation of a device within the dimensions of those currently available. Our findings confirm that the anatomy present within this age group is amenable to the placement of a 2 × 1 cm electrode array in 94% of patients examined. Our work serves to demonstrate the feasibility of implantable transclival devices for the provision of TTFs as a novel adjunctive therapy for DIPG.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059731 | PMC |
| http://dx.doi.org/10.3390/life13030601 | DOI Listing |
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