AI Article Synopsis
- The study investigates the relationship between cardiac function and postoperative metastasis (POM) in patients with stage I lung adenocarcinoma, suggesting that cardiac health can impact clinical outcomes.
- Of the 207 patients analyzed, it was found that the mitral valve peak A velocity adjusted for BMI (MVPABMI) is a significant predictor of POM, which also correlates with disease-free survival rates.
- This research introduces MVPABMI as a potential index for predicting POM in early-stage lung adenocarcinoma, marking an initial effort to link cardiac function parameters with cancer progression.
Article Abstract
Background: According to recent animal models for lung adenocarcinoma metastasis, cardiac function may be related to the clinical outcome. The aim of this study is to identify a predictable index for postoperative metastasis (POM) that is associated with cardiac function.
Methods: Two hundred and seven consecutive patients who underwent thoracoscopic resection for stage I lung adenocarcinoma were included. Disease-free survival (DFS), overall survival (OS), and patients' clinical and pathological characteristics were analyzed.
Results: Among the 207 patients, 17 cases demonstrated metastasis, 110 cases received a preoperative echocardiogram, and six cases had POM. Mitral valve peak A velocity, which is one of the left ventricular diastolic function parameters affected by BMI (MVPABMI), was associated with a negative factor for POM (hazard ratio (HR): 2.139, = 0.019) and a poor 5-year DFS in the above median (100% vs. 87%, = 0.014). The predictable rate increased from 30.7% to 75% when the MVPABMI was above the median = 3.15 in the solid subtype).
Conclusions: MVPABMI is a novel index for POM prediction in early-stage lung adenocarcinoma. This is a pilot study and the first attempt at research to verify that the diastole and the BMI may be associated with POM in early-stage lung adenocarcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054715 | PMC |
| http://dx.doi.org/10.3390/jpm13030497 | DOI Listing |
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