AI Article Synopsis
- The study investigates the clinical characteristics and survival outcomes of esophageal adenosquamous carcinoma (ADSC) using data from the Surveillance, Epidemiology, and End Results program, analyzing 137 patients between 2004 and 2018.
- Findings revealed a decreasing trend in the proportion of ADSC among esophageal cancer cases over the years, with no significant survival difference between ADSC and squamous cell carcinoma (SCC) but a worse prognosis compared to adenocarcinoma (ADC).
- Results suggest that combined treatment involving surgery significantly improves survival rates for ADSC patients, with surgical resection, radiotherapy, and chemotherapy identified as strong independent prognostic factors.
Article Abstract
There are few studies on esophageal adenosquamous carcinoma (ADSC). Our study intended to investigate the clinical and survival features of ADSC. We included esophageal cancer (EC) data from the Surveillance, Epidemiology, and End Results program database to explore clinical and survival traits. Propensity score matching (PSM), the multivariate Cox regression model, and survival curves were used in this study. A total of 137 patients with ADSC were included in our analysis. The proportion of ADSC within the EC cohort declined from 2004 to 2018. Besides, results indicated no significant difference in survival between ADSC and SCC groups (PSM-adjusted HR = 1.249, = 0.127). However, the survival rate of the ADSC group was significantly worse than that of the ADC group (PSM-adjusted HR = 1.497, = 0.007). For the ADSC group, combined treatment with surgery had a higher survival rate than other treatment methods (all < 0.001). Surgical resection, radiotherapy, and chemotherapy were independent protective prognostic factors (all < 0.05). The proportion of ADSC has been declining from 2004 to 2018. The prognosis of ADSC is not significantly different from that of SCC but is worse than that of ADC. Surgery, radiotherapy, and chemotherapy could improve the prognosis of patients. Comprehensive treatment with surgery as the main treatment is more beneficial for some patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057829 | PMC |
| http://dx.doi.org/10.3390/jpm13030468 | DOI Listing |
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