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Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study. | LitMetric

AI Article Synopsis

  • Sedentary behavior (SB), particularly high screen time, may negatively impact telomere length (TL) in children, possibly due to inflammation.
  • A study analyzed data from 669 children at age 4 and 530 at age 8, linking higher SB with shorter TL at both ages.
  • Results indicated that kids with the most screen time (1.6-5.0 hours/day) had a shorter TL at age 4 and experienced greater decreases in TL from ages 4 to 8 compared to those with less screen time.

Article Abstract

Sedentary behaviour (SB) may be related to telomere length (TL) attrition due to a possible pro-inflammatory effect. This study examined the association between parent-reported sedentary behaviour (SB) and leukocyte TL at the age of 4 and telomere tracking from 4 to 8 years. In the Spanish birth cohort Infancia y Medio Ambiente (INMA) project, we analysed data from children who attended follow-up visits at age 4 (n = 669) and 8 (n = 530). Multiple robust regression models were used to explore the associations between mean daily hours of SB (screen time, other sedentary activities, and total SB) at 4 years categorised into tertiles and TL at 4 years and difference in TL rank between age 4 and 8, respectively. At the age of 4, the results showed that children with the highest screen time (1.6-5.0 h/day) had a shorter TL of -3.9% (95% CI: -7.4, -0.4; = 0.03) compared with children in the lowest tertile (0.0-1.0 h/day). Between 4 and 8 years, a higher screen time (highest tertile group vs. lowest tertile) was associated with a decrease in the LTL rank of -1.9% (95% CI: -3.8, -0.1; = 0.03) from 4 to 8 years. Children exposed to a higher screen time at 4 years were more prone to have shorter TL at 4 and between 4 and 8 years of age. This study supports the potential negative effect of SB during childhood on cellular longevity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048855PMC
http://dx.doi.org/10.3390/ijerph20065134DOI Listing

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