As an important member of the kindlin family, fermitin family member 1 (FERMT1) can interact with integrin and its aberrant expression involves multiple tumors. However, there are few systematic studies on in pancreatic carcinoma (PAAD). We used several public databases to analyze the expression level and clinicopathological characteristics of in PAAD. Meanwhile, the correlation between expression and diagnostic and prognostic value, methylation, potential biological function, immune infiltration, and sensitivity to chemotherapy drugs in PAAD patients were investigated. was significantly up-regulated in PAAD and correlated with T stage, and histologic grade. High expression was closely connected with poor prognosis and can be used to diagnose PAAD. Moreover, the methylation of six CpG sites of was linked to prognosis, and expression was significantly related to N6-methyladenosine (mA) modification. Functional enrichment analysis revealed that co-expression genes participated in diverse biological functions including necroptosis. In addition, the expression of was associated with immune cell infiltration and the expression of immune checkpoint molecules. Finally, overexpression may be sensitive to chemotherapy drugs such as Palbociclib, AM-5992 and TAE-226. can serve as a diagnostic and prognostic marker of PAAD, which is connected with immune cell infiltration and the modulation of mA and necroptosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048534 | PMC |
| http://dx.doi.org/10.3390/genes14030734 | DOI Listing |
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